Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges
Haojie Cai, Yaqian Zhao, Yifei Cai, Xiaomei Luo, Jianxiao Li, Yongsong Wu, Jiani Yang, Chao Wang, Yue Zhang, Hui Ding, Shanshan Cheng, Yu Wang · 2026
Read Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges by Haojie Cai, Yaqian Zhao, Yifei Cai, Xiaomei Luo, Jianxiao Li, Yongsong Wu, Jiani Yang, Chao Wang, Yue Zhang, Hui Ding, Shanshan Cheng, Yu Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13156766.txt.
Description
Haojie Cai and co-authors published a 2026 review of artificial antigen-presenting cells: built cells that show the marks of a tumor to T cells, the scouts, to wake them for the fight. Presenting cells do this in the body. Their use in care is limited: T cells grow slowly, targeting is weak, and costs run high. Built presenters dodge those limits.
The review sorts the built kinds and weighs their strengths and weaknesses. It walks through how they wake and grow T cells, how they can pierce the guard wall of the tumor itself, and how they pair with companion treatment paths. Clinical use is examined as well. Barriers stand in the way: no standard rules for their manufacture, and no regulatory framework yet. The team calls for cross-field work and artificial intelligence help in the designs, and for presenters that do more than one job.
Catalog record
| CREATOR | Haojie Cai, Yaqian Zhao, Yifei Cai, Xiaomei Luo, Jianxiao Li, Yongsong Wu, Jiani Yang, Chao Wang, Yue Zhang, Hui Ding, Shanshan Cheng, Yu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 156 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |