An inflammation-targeted lipid nanoparticle inhibiting ferroptosis for spinal cord injury repair
Yao Lv, Yujie Hu, Zixia Xu, Hangzhe Sun, Yixiao Lv, Xingtong Dong, Chengluo Ye, Guofeng Yu, Haoru Dong, Chuan Chang, Min Ge · 2026
Read An inflammation-targeted lipid nanoparticle inhibiting ferroptosis for spinal cord injury repair by Yao Lv, Yujie Hu, Zixia Xu, Hangzhe Sun, Yixiao Lv, Xingtong Dong, Chengluo Ye, Guofeng Yu, Haoru Dong, Chuan Chang, Min Ge (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13156758.txt.
Description
A spinal cord injury site drowns in inflammation, and a healing hormone, erythropoietin, cannot reach it in useful amounts when given plainly. Yao Lv and co-authors package in 2026 its messenger RNA inside a mannose-coated lipid nanoparticle that homes to inflammatory macrophages marked by the CD206 receptor. The particles gathered at the lesion and kept producing the hormone locally.
Treated mice showed calmer inflammation, fewer lost neurons, intact serotonin wiring, and far better movement. Gene scans revealed the treatment also throttled ferroptosis, an iron-driven cell death, by steadying iron handling and fat oxidation. The authors pitch the carrier for other inflamed nerve injuries.
Catalog record
| CREATOR | Yao Lv, Yujie Hu, Zixia Xu, Hangzhe Sun, Yixiao Lv, Xingtong Dong, Chengluo Ye, Guofeng Yu, Haoru Dong, Chuan Chang, Min Ge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |