The presynaptic protein bassoon is a biofluid biomarker of synaptic pathology in multiple sclerosis
Marcel S Woo, Nicola Rothammer, Lukas C Bal, Christoph Krisp, Mario Kreutzfeldt, Susanne Witt, Aleksandra Maleska Maceski, Bente Siebels, Lukas Raich, Christina Mayer, Ingo Winschel, Anne Willing, Benjamin Schattling, Simone Bauer, Hartmut Schlüter, Sina C Rosenkranz, Jens Kuhle, Jan-Patrick Stellma · 2026
Read The presynaptic protein bassoon is a biofluid biomarker of synaptic pathology in multiple sclerosis by Marcel S Woo, Nicola Rothammer, Lukas C Bal, Christoph Krisp, Mario Kreutzfeldt, Susanne Witt, Aleksandra Maleska Maceski, Bente Siebels, Lukas Raich, Christina Mayer, Ingo Winschel, Anne Willing, Benjamin Schattling, Simone Bauer, Hartmut Schlüter, Sina C Rosenkranz, Jens Kuhle, Jan-Patrick Stellma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13156686.txt.
Description
Marcel Woo and co-authors hunt for a blood and spinal fluid sign of synapse loss in multiple sclerosis, in a 2026 study. Synapses are the links between nerve cells, and their loss is a core feature of the disease. Yet doctors lack a clear way to tell when that loss is happening in a living patient.
Working first in mice with a model of the disease, the team found several synapse proteins fell in the brain, among them one called bassoon. The same loss showed in human tissue after death. The team then built a lab test for bassoon and measured it in fluid and blood from patients and controls. The study also tracked bassoon over time next to a known nerve damage marker, testing whether it can flag synapse harm.
Catalog record
| CREATOR | Marcel S Woo, Nicola Rothammer, Lukas C Bal, Christoph Krisp, Mario Kreutzfeldt, Susanne Witt, Aleksandra Maleska Maceski, Bente Siebels, Lukas Raich, Christina Mayer, Ingo Winschel, Anne Willing, Benjamin Schattling, Simone Bauer, Hartmut Schlüter, Sina C Rosenkranz, Jens Kuhle, Jan-Patrick Stellma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |