Phloridzin mitigates bleomycin-elicited lung fibrosis in Wistar rats: The interplay between antioxidant defenses, inflammatory processes, transforming growth factor beta 1, and autophagy
Naif MF Alenezi, Abeer Elkhoely, Ahmed M Kabel, Amany AE Ahmed · 2026
Read Phloridzin mitigates bleomycin-elicited lung fibrosis in Wistar rats: The interplay between antioxidant defenses, inflammatory processes, transforming growth factor beta 1, and autophagy by Naif MF Alenezi, Abeer Elkhoely, Ahmed M Kabel, Amany AE Ahmed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13156562.txt.
Description
Naif Alenezi and co-authors test whether a plant compound, phloridzin, protects rat lungs against scarring caused by the drug bleomycin, published in 2026. Lung fibrosis is a serious side effect that limits that drug's use. The study probed several linked mechanisms at once: antioxidant defenses, inflammation, a growth factor, and cell recycling.
Rats received the compound daily at two doses for five weeks, starting a week before the drug. Treated animals showed fewer inflammatory cells and less enzyme leakage in lung wash fluid, and more of the resident immune cells. A damage marker fell while a protective antioxidant rose. Key drivers of inflammation and scarring were suppressed, a cell-death marker fell, and a recycling protein was restored. Tissue examination confirmed the protection.
Catalog record
| CREATOR | Naif MF Alenezi, Abeer Elkhoely, Ahmed M Kabel, Amany AE Ahmed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |