The role of interleukin-1 beta as an early biomarker for renal dysfunction in Egyptian sickle cell disease patients
Nourhan Mohamed Nasr, Noha Khalifa Abd El Ghaffar, Shaimaa Mohamed El Asmar, Yasmin Mohamed Saber · 2026
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Description
Nourhan Mohamed Nasr and co-authors test whether a urine marker can catch kidney damage early in sickle cell disease. Kidney harm is a rising problem in young people with the disease, often starting with overworked filters and protein leaking into urine. The team compared forty-six Egyptian patients with forty-six healthy volunteers.
Patients showed overactive filtration, frequent protein leakage, and higher urine levels of the inflammation marker IL-1 beta. The marker rose as protein leakage rose and fell as filtration changed, tracking both standard signs closely. Blood and urine tests covered kidney and liver function for both groups. The authors propose the urine marker as a painless early warning of kidney injury, rooted in the inflammation that drives the damage.
Catalog record
| CREATOR | Nourhan Mohamed Nasr, Noha Khalifa Abd El Ghaffar, Shaimaa Mohamed El Asmar, Yasmin Mohamed Saber |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |