Significance of RGS13 expression in lupus B cells
Tomoya Nakajima, Koji Kitagori, Sohei Funakoshi, Mirei Shirakashi, Ryosuke Hiwa, Hideaki Tsuji, Shuji Akizuki, Ran Nakashima, Akio Morinobu, Hajime Yoshifuji · 2026
Read Significance of RGS13 expression in lupus B cells by Tomoya Nakajima, Koji Kitagori, Sohei Funakoshi, Mirei Shirakashi, Ryosuke Hiwa, Hideaki Tsuji, Shuji Akizuki, Ran Nakashima, Akio Morinobu, Hajime Yoshifuji (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13155577.txt.
Description
Tomoya Nakajima and colleagues find a signalling regulator enriched in lupus B cells. Their study from twenty twenty-six hunts proteins special to the disease cells. B cells drive much lupus damage through antibodies. A harmful subset expands during active disease.
Hundreds of genes were switched on only in lupus B cells. One regulator, RGS13, ranked among the top candidates. Its level tracked the main lupus antibody in patients. The harmful cell subset carried especially high levels. Receptor stimulation in the lab switched the gene on. Mouse knockouts will test what the protein does. A new marker may help track lupus activity.
Catalog record
| CREATOR | Tomoya Nakajima, Koji Kitagori, Sohei Funakoshi, Mirei Shirakashi, Ryosuke Hiwa, Hideaki Tsuji, Shuji Akizuki, Ran Nakashima, Akio Morinobu, Hajime Yoshifuji |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |