RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages
Edismauro Garcia Freitas-Filho, Isabella Zaidan, Daniel Leonardo Alzamora-Terrel, Carolina Bifano, Marlon Fortes-Rocha, Patrícia Alves de Castro, Renan Eugênio Araujo Piraine, Camila Figueiredo Pinzan, Caroline Patini de Rezende, Emilio Boada-Romero, Thomas Wileman, Fausto Almeida, Gustavo Henrique · 2026
Read RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages by Edismauro Garcia Freitas-Filho, Isabella Zaidan, Daniel Leonardo Alzamora-Terrel, Carolina Bifano, Marlon Fortes-Rocha, Patrícia Alves de Castro, Renan Eugênio Araujo Piraine, Camila Figueiredo Pinzan, Caroline Patini de Rezende, Emilio Boada-Romero, Thomas Wileman, Fausto Almeida, Gustavo Henrique (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13155314.txt.
Description
Edismauro Garcia Freitas-Filho leads a large team in a 2026 cell study on how macrophages kill swallowed fungi. One route tags the meal sac with a protein called LC3, which helps the sac mature and arm itself. The team asked which traffic switch turns that route on.
They pinpoint one form of the RAB5 switch family as required. It draws in the gear that makes a key fat signal and the burst of reactive oxygen that helps kill germs. It also ferries in a pump part needed for the LC3 tag. Without the switch, macrophages failed to clear a lung fungus.
Catalog record
| CREATOR | Edismauro Garcia Freitas-Filho, Isabella Zaidan, Daniel Leonardo Alzamora-Terrel, Carolina Bifano, Marlon Fortes-Rocha, Patrícia Alves de Castro, Renan Eugênio Araujo Piraine, Camila Figueiredo Pinzan, Caroline Patini de Rezende, Emilio Boada-Romero, Thomas Wileman, Fausto Almeida, Gustavo Henrique |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |