Buyang Huanwu Decoction promotes neurorepair after spinal cord injury through a Lactobacillus johnsonii–indole-3-lactic acid–AhR–PI3K/Akt axis
Jinwang Dong, Yang Cao, Xiujin Chen, Tao Xie, Xiaobo Zhang, Qingpeng Zhao, Cunhu Shi, Qiangqiang Miao, Zhengwei Xu, Liang Yan, Liang Dong · 2026
Read Buyang Huanwu Decoction promotes neurorepair after spinal cord injury through a Lactobacillus johnsonii–indole-3-lactic acid–AhR–PI3K/Akt axis by Jinwang Dong, Yang Cao, Xiujin Chen, Tao Xie, Xiaobo Zhang, Qingpeng Zhao, Cunhu Shi, Qiangqiang Miao, Zhengwei Xu, Liang Yan, Liang Dong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13154660.txt.
Description
Jinwang Dong and co-authors show that a traditional Chinese herbal formula aids nerve repair after spinal cord injury through the gut, published in 2026. Injury to the cord disrupts gut microbes, and that disruption affects recovery. The formula, Buyang Huanwu Decoction, was known to shift gut microbes, but whether that shift drives its benefits was unclear.
In a rat injury model, the formula improved movement, cut spinal inflammation, and helped nerve cells survive and regrow. It also restored gut function and cut gut inflammation. Transplanting gut microbes from treated rats passed on many of these gains. Profiling pointed to one gut species and a metabolite it makes, acting through a known receptor and signaling pathway in the cord.
Catalog record
| CREATOR | Jinwang Dong, Yang Cao, Xiujin Chen, Tao Xie, Xiaobo Zhang, Qingpeng Zhao, Cunhu Shi, Qiangqiang Miao, Zhengwei Xu, Liang Yan, Liang Dong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |