The ribosomal RNA synthesis ratio biomarker in Mycobacterium ulcerans for drug activity evaluation
Juan Calvet-Seral, Emma Sáez-López, Patricio R López-Expósito, Santiago Ferrer-Bazaga, Juan José Vaquero, Santiago Ramón-García, Alfonso Mendoza-Losana · 2026
Read The ribosomal RNA synthesis ratio biomarker in Mycobacterium ulcerans for drug activity evaluation by Juan Calvet-Seral, Emma Sáez-López, Patricio R López-Expósito, Santiago Ferrer-Bazaga, Juan José Vaquero, Santiago Ramón-García, Alfonso Mendoza-Losana (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13154490.txt.
Description
Juan Calvet-Seral and co-authors trial a molecular speedometer for drug action against Buruli ulcer. The disease, caused by Mycobacterium ulcerans, needs eight weeks of two antibiotics, and counting live bacteria the classic way is slow. Their gauge, the ribosomal RNA synthesis ratio, tracks how fast bacteria build ribosomes, a stand-in for metabolic drive.
In time-kill tests, drug mixes containing rifampicin plus amoxicillin-clavulanate crashed the ratio within three days, far ahead of older readouts. The signal bottomed out around a week, then crept back over the following weeks, hinting at survivors the older tests missed. The authors say the gauge can rank regimens for shorter treatment and guide coming clinical trials.
Catalog record
| CREATOR | Juan Calvet-Seral, Emma Sáez-López, Patricio R López-Expósito, Santiago Ferrer-Bazaga, Juan José Vaquero, Santiago Ramón-García, Alfonso Mendoza-Losana |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |