The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models
Pierre Gillotay, Sushant Bangru, Benjamin Dassy, Benoit Haerlingen, Meghna P Shankar, Barbara F Fonseca, Panos G Ziros, Sumeet P Singh, Gerasimos P Sykiotis, Mirian Romitti, Sabine Costagliola · 2026
Read The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models by Pierre Gillotay, Sushant Bangru, Benjamin Dassy, Benoit Haerlingen, Meghna P Shankar, Barbara F Fonseca, Panos G Ziros, Sumeet P Singh, Gerasimos P Sykiotis, Mirian Romitti, Sabine Costagliola (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13153729.txt.
Description
Pierre Gillotay and co-authors study a cell defense switch in the thyroid gland, in work published in 2026. The gland makes hormones that steer growth and body burn rate in nearly all tissues. Making those hormones needs peroxide, which strains the gland with oxygen harm that must be held in check. The switch, called Nrf2, turns on genes that clear such harm.
The team broke the switch in zebrafish embryos and in mouse stem-cell thyroid models. Both showed a shared flaw in hormone making. In fish the flaw may stem from poor iodine tagging of the hormone base. In the lab models it may stem from making too little of that base.
Catalog record
| CREATOR | Pierre Gillotay, Sushant Bangru, Benjamin Dassy, Benoit Haerlingen, Meghna P Shankar, Barbara F Fonseca, Panos G Ziros, Sumeet P Singh, Gerasimos P Sykiotis, Mirian Romitti, Sabine Costagliola |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |