Restoring disc matrix homeostasis: Dual-miRNA and human platelet lysate as a novel therapeutic strategy
Tara Ní Néill, Niamh Wilson, Jijo Thomas, Jake McDonnell, Stacey L. Darwish, Joseph S. Butler, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley · 2026
Read Restoring disc matrix homeostasis: Dual-miRNA and human platelet lysate as a novel therapeutic strategy by Tara Ní Néill, Niamh Wilson, Jijo Thomas, Jake McDonnell, Stacey L. Darwish, Joseph S. Butler, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13153650.txt.
Description
Tara Ni Neill and nine co-authors pair two gene silencers with blood extract to heal worn discs in a 2026 study. Worn spinal discs drive most low back pain, as their soft core dries and breaks down. Tiny RNA bits can mute the genes that chew the core, and past work showed a paired dose curbed that chewing in disc models.
The team added human platelet lysate, a growth-rich blood extract, to boost the heal side. Rat disc core cells fed the extract were tracked for core build and stress marks. The paired plan may restore the disc's balance better than RNA alone.
Catalog record
| CREATOR | Tara Ní Néill, Niamh Wilson, Jijo Thomas, Jake McDonnell, Stacey L. Darwish, Joseph S. Butler, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |