Injectable, electrosprayed RGD-coupled alginate hydrogel microcapsules enable enhanced viability and sustained release of mesenchymal stem cells
Dominic Karl M. Bolinas, Allan John R. Barcena, Archana Mishra, Marvin R. Bernardino, Francisco M. Heralde, Steven Y. Huang, Marites P. Melancon · 2026
Read Injectable, electrosprayed RGD-coupled alginate hydrogel microcapsules enable enhanced viability and sustained release of mesenchymal stem cells by Dominic Karl M. Bolinas, Allan John R. Barcena, Archana Mishra, Marvin R. Bernardino, Francisco M. Heralde, Steven Y. Huang, Marites P. Melancon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13152925.txt.
Description
Dominic Karl M Bolinas and six co-authors package stem cells in tiny gel beads that survive the syringe, in this 2026 study. Mesenchymal stem cells promise repair, but injection kills or scatters them before they can work. Alginate capsules can shelter them, and decorating the gel with RGD peptides, the grip points cells hold onto, had hinted at better survival.
Their platform electrosprays the peptide-coupled gel into microcapsules averaging 175 micrometers across, uniform and spherical, with an ordered microporous interior. The peptide decoration left the gel's swelling, stiffness, and loading efficiency essentially unchanged. Cells inside stayed round and alive: after fourteen days, viability in the coupled gel reached 91.3 percent against 84.9 percent in plain alginate. Release stayed sustained rather than dumping the cargo at once. The authors pitch the beads as an injectable, off-the-shelf way to keep therapeutic cells alive at the target.
Catalog record
| CREATOR | Dominic Karl M. Bolinas, Allan John R. Barcena, Archana Mishra, Marvin R. Bernardino, Francisco M. Heralde, Steven Y. Huang, Marites P. Melancon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |