Label-free paper-based electrochemical aptasensor with tunable selectivity for assessing neurotransmitter imbalance in Alzheimer’s disease
Silvia Dortez, Miriam Chávez, Ana Montero-Calle, Rodrigo Barderas, Marta Pacheco, Alberto Escarpa · 2026
Read Label-free paper-based electrochemical aptasensor with tunable selectivity for assessing neurotransmitter imbalance in Alzheimer’s disease by Silvia Dortez, Miriam Chávez, Ana Montero-Calle, Rodrigo Barderas, Marta Pacheco, Alberto Escarpa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13152916.txt.
Description
Silvia Dortez and colleagues print a disposable paper sensor that reads two brain messengers at once for Alzheimer assessment, in this study from twenty twenty-six. Dopamine and serotonin drift out of balance in the disease. Their sensor is an electrochemical aptasensor: DNA aptamers on gold nanoparticles, stuck to a paper electrode, catch each messenger, and the two oxidize at distinct voltages, letting one strip report both.
Tested on human left prefrontal cortex samples, the device separated healthy from Alzheimer-diagnosed tissue by the characteristic shifts in both transmitters, across the clinically relevant range. No labels or lab machinery are needed. The authors aim the platform at liquid-biopsy-style neurochemical monitoring and at organ-on-a-chip systems, where cheap, multiplexed sensing could flag neurodegeneration earlier than behavior does.
Catalog record
| CREATOR | Silvia Dortez, Miriam Chávez, Ana Montero-Calle, Rodrigo Barderas, Marta Pacheco, Alberto Escarpa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |