Human neural organoid modeling of diffuse midline glioma captures the complexity of patient tumors
Jack M. Shireman, Elliot Xie, Connie S. Lebakken, Sudarshawn Damodharan, Kailyn T. Parham, William D. Richards, Rintaro Hashizume, Christina Kendziorski, Mahua Dey · 2026
Read Human neural organoid modeling of diffuse midline glioma captures the complexity of patient tumors by Jack M. Shireman, Elliot Xie, Connie S. Lebakken, Sudarshawn Damodharan, Kailyn T. Parham, William D. Richards, Rintaro Hashizume, Christina Kendziorski, Mahua Dey (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13152894.txt.
Description
Jack Shireman and co-authors grow a childhood brain cancer inside human neural organoids, in this 2026 Europe PMC paper. Diffuse midline glioma is a lethal pediatric tumor with only palliative care, and progress is slowed by poor lab models: mice are costly and cell cultures lack the tumor's cellular neighborhood. The team used flat human organoids containing neurons, astrocytes and microglia.
Tumor cells from three patient-derived lines integrated into the organoids and grew well. Spatial gene-expression profiling showed tumor cells interacting individually with microglia and astrocytes, changing gene signatures on both sides. The model mirrors patient tumor complexity closely enough to support species-matched drug testing in a dish.
Catalog record
| CREATOR | Jack M. Shireman, Elliot Xie, Connie S. Lebakken, Sudarshawn Damodharan, Kailyn T. Parham, William D. Richards, Rintaro Hashizume, Christina Kendziorski, Mahua Dey |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |