When Lifelong Anosmia Reveals Hypogonadism: A Case of Kallmann Syndrome with Primary Amenorrhea
Jacklyn Yosefin Gracia Lubis, Artha Falentin Putri Susilo, Ruswana Anwar, Anita Rachmawati · 2026
Read When Lifelong Anosmia Reveals Hypogonadism: A Case of Kallmann Syndrome with Primary Amenorrhea by Jacklyn Yosefin Gracia Lubis, Artha Falentin Putri Susilo, Ruswana Anwar, Anita Rachmawati (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13151937.txt.
Description
Jacklyn Lubis and co-authors report a delayed diagnosis in a young woman in a 2026 case paper. She had never menstruated on her own and had never been able to smell. Those two signs together point to Kallmann syndrome, a rare genetic disorder where the brain fails to trigger puberty and the smell bulbs do not form. In women the signs can be subtle, so the disorder is often missed.
The patient, aged twenty-five, had partial breast and body development, which first led doctors astray. Scans showed a small womb and ovaries, and blood tests showed low estrogen with low trigger hormones. Brain imaging found no smell bulbs, which settled the diagnosis. Bone scans showed thin bones from years of low estrogen. She began hormone therapy plus calcium and vitamin D. Care also covered fertility planning and mental health checks.
Catalog record
| CREATOR | Jacklyn Yosefin Gracia Lubis, Artha Falentin Putri Susilo, Ruswana Anwar, Anita Rachmawati |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |