Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5′-nucleotidase and NTPDase inhibitors
Zahra Batool, Shireen Mona Dutt, Mariya al-Rashida, Nicolly Espindola Gelsleichter, Julie Pelletier, Jean Sévigny, Talha Islam, Mostafa A Ismail, Ajmal Khan, Halil Şenol, Rima D Alharthy, Jamshed Iqbal, Zahid Shafiq · 2026
Read Synthesis, biological evaluation and molecular docking studies of N-propylsulfonyl indole-linked hydrazinecarbothioamides as selective ecto-5′-nucleotidase and NTPDase inhibitors by Zahra Batool, Shireen Mona Dutt, Mariya al-Rashida, Nicolly Espindola Gelsleichter, Julie Pelletier, Jean Sévigny, Talha Islam, Mostafa A Ismail, Ajmal Khan, Halil Şenol, Rima D Alharthy, Jamshed Iqbal, Zahid Shafiq (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13149843.txt.
Description
Zahra Batool and co-authors build a library of new compounds that block enzymes which turn a cell fuel into a calming signal, in a 2026 study. Those enzymes shape immune response, swelling, and cancer growth. Blocking the right one, and only that one, is the prize.
Twenty-two compounds in the new family were made and checked. Four stood out, blocking the target at low doses with clear taste for one enzyme form over its kin. Studies of shape showed which parts drove the strength. Computer models placed the winners snugly in the enzyme pocket, and long simulations held them steady. The work names leads for drug design.
Catalog record
| CREATOR | Zahra Batool, Shireen Mona Dutt, Mariya al-Rashida, Nicolly Espindola Gelsleichter, Julie Pelletier, Jean Sévigny, Talha Islam, Mostafa A Ismail, Ajmal Khan, Halil Şenol, Rima D Alharthy, Jamshed Iqbal, Zahid Shafiq |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |