Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps, and barriers to CIPN biomarker implementation in clinical practice—a narrative review
Paola Alberti, Sara Faithfull, Andreas A Argyriou, David Balayssac, Daniel L Hertz, Maryam Lustberg, Susanna B Park, Tiffany Li, Mary Tanay, Terri Jabaley, Lise Worthen-Chaudhari, Ellen M L Smith · 2026
Read Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps, and barriers to CIPN biomarker implementation in clinical practice—a narrative review by Paola Alberti, Sara Faithfull, Andreas A Argyriou, David Balayssac, Daniel L Hertz, Maryam Lustberg, Susanna B Park, Tiffany Li, Mary Tanay, Terri Jabaley, Lise Worthen-Chaudhari, Ellen M L Smith (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13149631.txt.
Description
Paola Alberti and co-authors review whether a blood protein can warn which cancer patients will suffer nerve damage from chemotherapy. The side effect affects about 70 percent of patients on certain drugs, and roughly 30 percent keep chronic symptoms that erode daily life. The candidate marker, serum neurofilament light chain, rises when nerve fibres are injured. The review grew out of an expert workshop that weighed the evidence and the gaps.
Eleven studies found that rises in the marker after two or three chemotherapy doses tracked how severe the nerve damage later became. Yet marker levels varied widely between studies, as did the drugs, doses, and measures used, so the experts judged it not ready for routine care. The authors lay out the validation steps still needed and the barriers to bringing any such marker into clinics.
Catalog record
| CREATOR | Paola Alberti, Sara Faithfull, Andreas A Argyriou, David Balayssac, Daniel L Hertz, Maryam Lustberg, Susanna B Park, Tiffany Li, Mary Tanay, Terri Jabaley, Lise Worthen-Chaudhari, Ellen M L Smith |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |