Renal proteomics of male offspring exposed to maternal protein restriction: molecular, epigenetic, and nephron-specific signatures of metabolic programming
Danielle Amanda Niz Alvarez, Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Marina Pereira Pires, Luisa Annibal Barata, Flávia Alessandra Maciel, Luiz Marcos Frediane Portela, Renato Mattos, Hecttor Sebastian Baptista, Pedro Menchini Vitali¹, Vinicius Alexandre Andrade Felipe, Marcel Rodrigues Ferr · 2026
Read Renal proteomics of male offspring exposed to maternal protein restriction: molecular, epigenetic, and nephron-specific signatures of metabolic programming by Danielle Amanda Niz Alvarez, Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Marina Pereira Pires, Luisa Annibal Barata, Flávia Alessandra Maciel, Luiz Marcos Frediane Portela, Renato Mattos, Hecttor Sebastian Baptista, Pedro Menchini Vitali¹, Vinicius Alexandre Andrade Felipe, Marcel Rodrigues Ferr (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13149610.txt.
Description
Alvarez, Ribeiro, Fioretto and colleagues studied how low protein intake by mother rats affects the kidneys of their male offspring in 2026. Using a global proteomic scan of kidney tissue after weaning, they compared pups from protein-restricted mothers with controls.
The restricted group showed weakened networks for energy metabolism, ion transport and mitochondrial function, while immune pathways and glutathione metabolism were turned up. Key proteins tied to these shifts included GPX1, CYCS and sodium-potassium pump subunits. Pathway analysis linked the pattern to later risks of high blood pressure, acid-base imbalance and kidney failure. The work supports the idea that early nutrition programmes long-term kidney health.
Catalog record
| CREATOR | Danielle Amanda Niz Alvarez, Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Marina Pereira Pires, Luisa Annibal Barata, Flávia Alessandra Maciel, Luiz Marcos Frediane Portela, Renato Mattos, Hecttor Sebastian Baptista, Pedro Menchini Vitali¹, Vinicius Alexandre Andrade Felipe, Marcel Rodrigues Ferr |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |