Ultrasound modulates microglial activity and reduces neuroinflammation in a parameter-dependent manner
Sarina Grewal, Francesco Iacoponi, Lok Yin Nicholas Chan, Valeria Dosso, William Lim Kee Chang, Vanessa Drevenakova, Albert Ugwudike, Leonardo Ricotti, Paul M. Matthews, Andrea Cafarelli, Sophie V. Morse · 2026
Read Ultrasound modulates microglial activity and reduces neuroinflammation in a parameter-dependent manner by Sarina Grewal, Francesco Iacoponi, Lok Yin Nicholas Chan, Valeria Dosso, William Lim Kee Chang, Vanessa Drevenakova, Albert Ugwudike, Leonardo Ricotti, Paul M. Matthews, Andrea Cafarelli, Sophie V. Morse (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13149327.txt.
Description
Sarina Grewal and co-authors test whether focused ultrasound can calm the brain's immune cells and ease neuroinflammation. They swept a wide range of sound settings on immune cells grown in dishes, stirred into inflammation by a bacterial toxin. Certain mixes of pitch, pressure, and dose stood out.
The best settings cut three inflammatory signals for up to three days and dialed down a master inflammation switch. In live mice given the same toxin, ultrasound lowered one key signal in the memory center of the brain. The authors pitch ultrasound as a drug-free way to cool brain inflammation.
Catalog record
| CREATOR | Sarina Grewal, Francesco Iacoponi, Lok Yin Nicholas Chan, Valeria Dosso, William Lim Kee Chang, Vanessa Drevenakova, Albert Ugwudike, Leonardo Ricotti, Paul M. Matthews, Andrea Cafarelli, Sophie V. Morse |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |