Stress Accelerates Depressive-Like Behaviors through Increase of Notch2 Expression in N141I Mutation Presenilin-2 Transgenic Mice
Seung Sik Yoo, Sun Mi Gu, Kyung Tak Nam, Jeong Soon Choi, Yong Sun Lee, In Jun Yeo, Ji Eun Yu, Sanghyeon Kim, Dong Won Lee, Hyeon Joo Ham, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong · 2026
Read Stress Accelerates Depressive-Like Behaviors through Increase of Notch2 Expression in N141I Mutation Presenilin-2 Transgenic Mice by Seung Sik Yoo, Sun Mi Gu, Kyung Tak Nam, Jeong Soon Choi, Yong Sun Lee, In Jun Yeo, Ji Eun Yu, Sanghyeon Kim, Dong Won Lee, Hyeon Joo Ham, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13149050.txt.
Description
Seung Sik Yoo and co-authors link chronic stress, depression-like behavior, and Alzheimer's disease in a 2026 study of mice. The mice carried a gene change tied to an early-onset form of the disease. After four weeks of mild, unpredictable stress, the altered mice lost interest in sweet water and gave up sooner in swim and hanging tests, while normal mice did not.
Stress also raised a stress hormone in the blood and boosted a signaling path in the brain built around a protein called Notch2. Human brain data showed the same signal raised in people with Alzheimer's disease and depression. A drug that blocks the path restored normal behavior in the mice. The authors name Notch2 as a shared thread worth targeting in both conditions.
Catalog record
| CREATOR | Seung Sik Yoo, Sun Mi Gu, Kyung Tak Nam, Jeong Soon Choi, Yong Sun Lee, In Jun Yeo, Ji Eun Yu, Sanghyeon Kim, Dong Won Lee, Hyeon Joo Ham, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |