Evaluating Baricitinib for Severe Paediatric Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) with Single-Cell Sequencing
Danyang Yang, Xin Liu, Wenwen Jing, Xu Feng, Canying Lai, Chenyue Liu, Zhigang Xu, Yangang Zhang, Jiayi Han, Songmei Geng, Ruilian Li, Dan Li, Boyi Cheng, Yufei Wu, Zhuokun Liu, Jialin Lian, Zhenghui Wang, Yale Liu, Xiaoli Li · 2026
Read Evaluating Baricitinib for Severe Paediatric Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) with Single-Cell Sequencing by Danyang Yang, Xin Liu, Wenwen Jing, Xu Feng, Canying Lai, Chenyue Liu, Zhigang Xu, Yangang Zhang, Jiayi Han, Songmei Geng, Ruilian Li, Dan Li, Boyi Cheng, Yufei Wu, Zhuokun Liu, Jialin Lian, Zhenghui Wang, Yale Liu, Xiaoli Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13148270.txt.
Description
Danyang Yang and colleagues report a hard case of a severe drug reaction in a three-year-old boy. The reaction, called DRESS, brings fever, rash, and harm to organs, and it can kill. The boy's case was set off by a seizure drug and did not yield to strong standard care. The team read gene activity cell by cell in his blood and skin to find a better target.
The reads pointed to a signaling path blocked by the drug baricitinib. On that drug, the rash cleared, blood counts and liver tests settled, and steroids could be eased off. The case backs gene-guided drug choice for the worst reactions.
Catalog record
| CREATOR | Danyang Yang, Xin Liu, Wenwen Jing, Xu Feng, Canying Lai, Chenyue Liu, Zhigang Xu, Yangang Zhang, Jiayi Han, Songmei Geng, Ruilian Li, Dan Li, Boyi Cheng, Yufei Wu, Zhuokun Liu, Jialin Lian, Zhenghui Wang, Yale Liu, Xiaoli Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |