Postoperative drainage after pancreatoduodenectomy: a randomized controlled trial among patients with intermediate and low risks for pancreatic fistula—DRAIN1
Sebastian Wallon, Caroline Williamsson, Victor Karlsson, Johanna Wennerblom, Svein-Olav Bratlie, Per Sandström, Bobby Tingstedt, Bergthor Björnsson · 2026
Read Postoperative drainage after pancreatoduodenectomy: a randomized controlled trial among patients with intermediate and low risks for pancreatic fistula—DRAIN1 by Sebastian Wallon, Caroline Williamsson, Victor Karlsson, Johanna Wennerblom, Svein-Olav Bratlie, Per Sandström, Bobby Tingstedt, Bergthor Björnsson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13147858.txt.
Description
Sebastian Wallon and co-authors lay out a randomized trial asking whether drains are needed after a major pancreas operation, in a 2026 protocol. Surgeons long placed drains after pancreatoduodenectomy, fearing leaks of pancreatic juice. A 2014 trial linked skipping drains to higher deaths, but it lumped all risk levels together. Low-risk patients might safely skip them, early evidence hints.
The DRAIN1 trial enrolls patients at low or intermediate leak risk, scores each one's risk, and randomizes drain or no drain across centers. Morbidity odds will be compared with regression models. The authors aim to settle whether the old gold standard still earns its place for the safer half of patients. The protocol frames the trial before results arrive.
Catalog record
| CREATOR | Sebastian Wallon, Caroline Williamsson, Victor Karlsson, Johanna Wennerblom, Svein-Olav Bratlie, Per Sandström, Bobby Tingstedt, Bergthor Björnsson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |