Integrative circulatory engineering for regenerative therapy: Dynamic perfusion design and metabolic maturation in cardiac tissue engineering
Jun Homma, Hidekazu Sekine · 2026
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Description
Jun Homma and Hidekazu Sekine propose a joined-up way to engineer replacement heart tissue in a 2026 review. Lab-grown heart muscle still beats like fetal tissue and lacks a working vessel network. As cells are pushed toward adult metabolism, their oxygen hunger rises, exposing weak vessel design.
The authors argue that metabolism, vessel layout, and flow should be designed together, not tuned one by one. Scaffold-free tissues, where cells touch directly and form their own micro-vessels, are singled out as a strong platform. The review covers how cell mix, neighbor signals, matrix stiffness, and patterning can align supply with demand. Flow reactors are treated as part of the circulation, shaping vessel growth with controlled oxygen and shear.
Catalog record
| CREATOR | Jun Homma, Hidekazu Sekine |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |