Theobromine is associated with slower epigenetic ageing
Ramy Saad, Ricardo Costeira, Pamela R. Matías-García, Sergio Villicaña, Christian Gieger, Karsten Suhre, Annette Peters, Gabi Kastenmüller, Ana Rodriguez-Mateos, Cristina Dias, Cristina Menni, Melanie Waldenberger, Jordana T. Bell · 2025
Read Theobromine is associated with slower epigenetic ageing by Ramy Saad, Ricardo Costeira, Pamela R. Matías-García, Sergio Villicaña, Christian Gieger, Karsten Suhre, Annette Peters, Gabi Kastenmüller, Ana Rodriguez-Mateos, Cristina Dias, Cristina Menni, Melanie Waldenberger, Jordana T. Bell (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13147728.txt.
Description
Ramy Saad and co-authors link a cocoa compound to slower aging marks in a 2025 study. The compound is theobromine, the mild stimulant in cocoa and chocolate. It has been tied to longer life in simple organisms and to health gains in people. The team asked whether blood levels of it track with epigenetic aging, the chemical marks on DNA that gauge how fast a body ages.
In a British twin cohort of about five hundred people, higher theobromine went with slower aging on two DNA measures. The same links appeared in a German cohort of over a thousand people. Checks against other cocoa and coffee compounds suggested the effect belongs to theobromine itself. The authors say diet may reach down to the molecular marks of aging. They call the finding a lead for deeper study, not yet a prescription.
Catalog record
| CREATOR | Ramy Saad, Ricardo Costeira, Pamela R. Matías-García, Sergio Villicaña, Christian Gieger, Karsten Suhre, Annette Peters, Gabi Kastenmüller, Ana Rodriguez-Mateos, Cristina Dias, Cristina Menni, Melanie Waldenberger, Jordana T. Bell |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |