Age-varying DNA methylation patterns associated with blood pressure in mid-to-late adulthood
Gang Xu, Xiaowei Zhuang, Amei Amei, Zuoheng Wang, Edwin C Oh · 2026
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Description
Gang Xu and co-authors study, in a 2026 paper, how the link between DNA marks and blood pressure shifts with age. Chemical marks on DNA, called methylation, can turn genes up or down. Past studies tied marks to blood pressure at a single point in life. This team used repeat blood samples from nearly a thousand adults in a long-running heart study, and modeled how each mark's effect changes across the years.
Six marks showed age-dependent links to systolic or pulse pressure. Two of them, in genes named STIP1 and CSRP1, checked out again in a second large cohort. Some marks even flipped direction with age, raising pressure in younger adults but lowering it later. The tied pathways involve vessel wall structure and repair. Two dozen approved drugs touch genes at these spots.
Catalog record
| CREATOR | Gang Xu, Xiaowei Zhuang, Amei Amei, Zuoheng Wang, Edwin C Oh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |