ABSTRACT NUMBER: ESOC2026A278 INHIBITION OF THE NLRP3 INFLAMMASOME REDUCES NEUROINFLAMMATION AND IMPROVES FUNCTIONAL OUTCOMES IN ACUTE ISCHEMIC STROKE: A TRANSLATIONAL EXPERIMENTAL STUDY
Jagat Pal Yadav · 2026
Read ABSTRACT NUMBER: ESOC2026A278 INHIBITION OF THE NLRP3 INFLAMMASOME REDUCES NEUROINFLAMMATION AND IMPROVES FUNCTIONAL OUTCOMES IN ACUTE ISCHEMIC STROKE: A TRANSLATIONAL EXPERIMENTAL STUDY by Jagat Pal Yadav (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13146931.txt.
Description
Jagat Pal Yadav tested whether blocking an inflammation switch in the brain can limit stroke damage. The switch, called the NLRP3 inflammasome, drives swelling and cell death after a stroke blocks blood flow. Yadav used a rat model of stroke to test a drug that targets it. The drug, MCC950, is known to block this pathway with precision.
Forty-eight rats had a brain artery blocked for a short time. Half got the drug when flow returned and again a day later, and half got a dummy shot. Treated rats had brain damage about a third smaller than controls. Their movement and nerve scores were better at one and three days. Levels of the switch and its partner proteins fell sharply, and the blood-brain barrier held up better. No side effects appeared.
Catalog record
| CREATOR | Jagat Pal Yadav |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |