ABSTRACT NUMBER: ESOC2026A1926 EFFECTS OF ACUTE THYROID RECEPTOR MODULATION IN EXPERIMENTAL ISCHEMIC STROKE
Angelos Pavlopoulos, Nefeli Zerva, Asterios Kokkonakis, Ioannis Tatsidis, Anastasia Papavasileiou, Michail Georgopoulos, Vasiliki Aggeli, Eleni Kaliatsi, Aimilios Papaioannou, Constantinos Pantos, Iordanis Mourouzis, Athanasios Lourbopoulos · 2026
Read ABSTRACT NUMBER: ESOC2026A1926 EFFECTS OF ACUTE THYROID RECEPTOR MODULATION IN EXPERIMENTAL ISCHEMIC STROKE by Angelos Pavlopoulos, Nefeli Zerva, Asterios Kokkonakis, Ioannis Tatsidis, Anastasia Papavasileiou, Michail Georgopoulos, Vasiliki Aggeli, Eleni Kaliatsi, Aimilios Papaioannou, Constantinos Pantos, Iordanis Mourouzis, Athanasios Lourbopoulos (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13146655.txt.
Description
Thyroid hormone speeds the body's engines, and its role after stroke has puzzled researchers, with studies pointing both ways. Angelos Pavlopoulos and co-authors test hormone push and block in ninety mice with a temporary blocked brain artery, in this 2026 conference report. Animals received the hormone T3 at two doses, one of two receptor blockers, or a thyroid-mimicking drug, starting at reperfusion.
The results disappoint any simple hope. High-dose T3 did not shrink the injury, the swelling, or the neuron loss. Low-dose T3 actually worsened survival of neurons in the threatened rim around the injury. Blocking the receptors made clinical scores worse with larger injuries. The team's new staining method, which separates the salvageable rim from dead core, grounded the readings. Timing and dose, the report implies, decide whether thyroid signals help or harm.
Catalog record
| CREATOR | Angelos Pavlopoulos, Nefeli Zerva, Asterios Kokkonakis, Ioannis Tatsidis, Anastasia Papavasileiou, Michail Georgopoulos, Vasiliki Aggeli, Eleni Kaliatsi, Aimilios Papaioannou, Constantinos Pantos, Iordanis Mourouzis, Athanasios Lourbopoulos |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |