ABSTRACT NUMBER: ESOC2026A674 NET CLINICAL BENEFIT OF STARTING ANTICOAGULATION EARLY AFTER ISCHEMIC STROKE IN ATRIAL FIBRILLATION: A META-ANALYSIS OF RANDOMIZED TRIALS FROM THE CATALYST COLLABORATION
Alexandros Polymeris, Konstantina Chalkou, Georgia Salanti, Hakim-Moulay Dehbi, Jonas Oldgren, Truman Milling, Steven Warach, Signild Åsberg, David Werring, Urs Fischer · 2026
Read ABSTRACT NUMBER: ESOC2026A674 NET CLINICAL BENEFIT OF STARTING ANTICOAGULATION EARLY AFTER ISCHEMIC STROKE IN ATRIAL FIBRILLATION: A META-ANALYSIS OF RANDOMIZED TRIALS FROM THE CATALYST COLLABORATION by Alexandros Polymeris, Konstantina Chalkou, Georgia Salanti, Hakim-Moulay Dehbi, Jonas Oldgren, Truman Milling, Steven Warach, Signild Åsberg, David Werring, Urs Fischer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13146608.txt.
Description
Alexandros Polymeris and co-authors pool, in a 2026 conference abstract, four trials on when to start blood thinners after a stroke caused by atrial fibrillation. Starting early cuts the combined risk of later strokes of both kinds. Whether it wins once the differing weights of those events are counted was unclear.
The CATALYST group combined individual data on 5,429 patients. One arm started the drugs within four days, the other at five days or later. The analysis was prespecified, a guard against cherry-picking. Net clinical benefit weighs a prevented clot against a caused bleed, which patients experience very differently. The answer guides a daily decision on stroke wards worldwide.
Catalog record
| CREATOR | Alexandros Polymeris, Konstantina Chalkou, Georgia Salanti, Hakim-Moulay Dehbi, Jonas Oldgren, Truman Milling, Steven Warach, Signild Åsberg, David Werring, Urs Fischer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |