ABSTRACT NUMBER: ESOC2026A944 MICROGLIAL CATABOLIC DEFECT OF BRANCHED-CHAIN AMINO ACIDS PROMOTES POST-STROKE NEUROINFLAMMATION AND ACUTE ISCHEMIC BRAIN INJURY
Huiya Li, Pinyi Liu, Qi Li, Siyuan Zhang, Shiji Deng, Yun Xu · 2026
Read ABSTRACT NUMBER: ESOC2026A944 MICROGLIAL CATABOLIC DEFECT OF BRANCHED-CHAIN AMINO ACIDS PROMOTES POST-STROKE NEUROINFLAMMATION AND ACUTE ISCHEMIC BRAIN INJURY by Huiya Li, Pinyi Liu, Qi Li, Siyuan Zhang, Shiji Deng, Yun Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13146578.txt.
Description
Huiya Li and co-authors trace post-stroke brain inflammation to a feeding failure inside microglia, the brain's resident immune cells. Their 2026 conference study builds on maps that found two microglial groups after stroke: one in the dead core and one in the salvageable rim. The core group had shut down its breakdown of branched-chain amino acids, which then piled up.
Boosting that breakdown in mice calmed inflammation, shrank the core group, and lessened injury. A gene regulator called Arid3a emerged as the upstream switch for the whole pathway. Silencing it worsened strokes; raising it protected the brain in the acute phase. Drug treatment that pushed the same pathway also shifted cell metabolism. The authors name Arid3a a promising target for limiting stroke damage.
Catalog record
| CREATOR | Huiya Li, Pinyi Liu, Qi Li, Siyuan Zhang, Shiji Deng, Yun Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |