GDF15 in aging, metabolic disease and cachexia
Shuli Lian · 2026
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Description
Shuli Lian reviews a stress protein called GDF15 in aging and disease in a 2026 article. The protein rises when cells are stressed by failing power plants, inflammation, or other strain, and its receptor in the hindbrain, found less than a decade ago, controls appetite and energy balance. Levels climb steeply with age, making it one of the most raised proteins of old age.
High levels track with weakness, poor nutrition, low appetite, fading memory, and low mood in older adults, and with frailty in kidney disease. The article discusses a study in this issue linking the protein to muscle wasting and anemia in kidney patients. It also notes a split role in the kidney, where the protein may protect tissue even as high blood levels mark worse outcomes.
Catalog record
| CREATOR | Shuli Lian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |