APOE4 Drives Sex‐ and Diet‐Dependent Effects on AD‐Like Pathology, Cognition, and Mitochondrial Function
Chelsea N. Johnson, Colton R. Lysaker, Xin Cao, Vivien Csikos, Frederick Boakye, Paul J. Kueck, Edziu Franczak, Paige C. Geiger, Jill K. Morris, John P. Thyfault, Heather M. Wilkins · 2026
Read APOE4 Drives Sex‐ and Diet‐Dependent Effects on AD‐Like Pathology, Cognition, and Mitochondrial Function by Chelsea N. Johnson, Colton R. Lysaker, Xin Cao, Vivien Csikos, Frederick Boakye, Paul J. Kueck, Edziu Franczak, Paige C. Geiger, Jill K. Morris, John P. Thyfault, Heather M. Wilkins (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13146351.txt.
Description
Chelsea Johnson and co-authors test how a risk gene, sex, and diet work together in Alzheimer like disease in mice in a 2026 study. The gene form APOE4 is the strongest known genetic risk factor for the disease in humans, yet how it drives harm is unclear. Diet and sex may change that risk.
Mice carrying the human APOE3 or APOE4 form ate a low fat or high fat diet from four to eight months of age. The team measured blood markers, brain plaque protein, learning, and the energy units of brain cells. APOE4 lowered brain APOE levels and impaired learning before the diet began. Its effects on cell energy paths differed by sex and diet.
Catalog record
| CREATOR | Chelsea N. Johnson, Colton R. Lysaker, Xin Cao, Vivien Csikos, Frederick Boakye, Paul J. Kueck, Edziu Franczak, Paige C. Geiger, Jill K. Morris, John P. Thyfault, Heather M. Wilkins |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |