GSH-responsive nanovaccine triggers immunogenic cell death and potent memory T cell immunity for durable, recurrence-free tumor eradication
Khang-Yen Pham, Thu Huyen Le Thi, Anil Giri, Jongjun Park, Jong-Sun Kang, Taeg Kyu Kwon, Jee-Heon Jeong, Simmyung Yook · 2026
Read GSH-responsive nanovaccine triggers immunogenic cell death and potent memory T cell immunity for durable, recurrence-free tumor eradication by Khang-Yen Pham, Thu Huyen Le Thi, Anil Giri, Jongjun Park, Jong-Sun Kang, Taeg Kyu Kwon, Jee-Heon Jeong, Simmyung Yook (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13145900.txt.
Description
Khang-Yen Pham and co-authors build a nanovaccine meant to make tumors destroy themselves while training lasting immunity, in a 2026 paper. Cancer vaccines often fade, and tumors return. Their particle, named SHINE, is a hollow shell of manganese oxide built to fall apart only inside tumors, where a molecule called glutathione runs high.
Breaking down, the shell drains that molecule and releases manganese ions that spark toxic radicals, killing tumor cells in a way that alerts the immune system. The particle also frees an immune stimulant and carries an antibody that lifts a brake on immune cells. The goal is memory T cells that patrol for relapse. Durable, relapse-free control is the prize this combined design chases.
Catalog record
| CREATOR | Khang-Yen Pham, Thu Huyen Le Thi, Anil Giri, Jongjun Park, Jong-Sun Kang, Taeg Kyu Kwon, Jee-Heon Jeong, Simmyung Yook |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |