ABSTRACT NUMBER: ESOC2026A1019 CEREBRAL COLLATERAL STATUS AND OUTCOMES WITH ADJUNCTIVE INTRA-ARTERIAL ALTEPLASE AFTER SUCCESSFUL ENDOVASCULAR REPERFUSION FOR ACUTE LARGE VESSEL OCCLUSION STROKE: SUBGROUP ANALYSIS OF THE PEARL TRIAL
Xiaoming Rong, Xuejing Lin, Zhenhong Deng, Yanting Chen, Jinyuan Wang, Mengqi Liu, Yaxuan Pi, Yongteng Xu, Xinguang Yang, Songhua Xiao, Yamei Tang · 2026
Read ABSTRACT NUMBER: ESOC2026A1019 CEREBRAL COLLATERAL STATUS AND OUTCOMES WITH ADJUNCTIVE INTRA-ARTERIAL ALTEPLASE AFTER SUCCESSFUL ENDOVASCULAR REPERFUSION FOR ACUTE LARGE VESSEL OCCLUSION STROKE: SUBGROUP ANALYSIS OF THE PEARL TRIAL by Xiaoming Rong, Xuejing Lin, Zhenhong Deng, Yanting Chen, Jinyuan Wang, Mengqi Liu, Yaxuan Pi, Yongteng Xu, Xinguang Yang, Songhua Xiao, Yamei Tang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13145618.txt.
Description
Xiaoming Rong and co-authors report a subgroup analysis of the PEARL stroke trial, listed as abstract ESOC2026A1019 and published in 2026. The trial tested an added clot-busting drug, given into an artery right after a blocked brain vessel had been reopened by a device. The question here was whether backup blood flow routes, called collaterals, change who gains from the extra drug. Scans rated those routes as good or poor.
The analysis covered 235 patients with collateral ratings, most of them rated good. Among patients with good routes, the added drug raised the share with near-full recovery at ninety days. Among patients with poor routes, no clear gain appeared. Harm rates, such as brain bleeding, were tracked as safety checks. No firm statistical link between route quality and drug effect was proven. The authors still flag collateral status as a clue worth weighing.
Catalog record
| CREATOR | Xiaoming Rong, Xuejing Lin, Zhenhong Deng, Yanting Chen, Jinyuan Wang, Mengqi Liu, Yaxuan Pi, Yongteng Xu, Xinguang Yang, Songhua Xiao, Yamei Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |