ABSTRACT NUMBER: ESOC2026A1518 BLOOD-BRAIN BARRIER DISRUPTION IN PATIENTS WITH INCIDENTAL WHITE MATTER HYPERINTENSITIES
Richard Leigh, Sarvin Sasannia, Shimeng Wang, Jinwei Zhang, Jerry Prince, Lew Becker, Dhananjay Vaidya, Peter van Zijl, Linda Knutsson, Paul Nyquist · 2026
Read ABSTRACT NUMBER: ESOC2026A1518 BLOOD-BRAIN BARRIER DISRUPTION IN PATIENTS WITH INCIDENTAL WHITE MATTER HYPERINTENSITIES by Richard Leigh, Sarvin Sasannia, Shimeng Wang, Jinwei Zhang, Jerry Prince, Lew Becker, Dhananjay Vaidya, Peter van Zijl, Linda Knutsson, Paul Nyquist (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13145445.txt.
Description
Richard Leigh and nine colleagues studied bright spots that often show up on brain scans of healthy older adults. These spots, called white matter hyperintensities, are usually blamed on normal aging. The team asked whether leaks in the blood-brain barrier help explain them. That barrier is the wall that guards the brain from the blood.
The study drew on a long-running cohort whose members had brain scans thirteen years apart. About three hundred fifteen people took part, with a median age of sixty-four. Leak levels at the later scan matched closely with spot volume at that same visit. Growth in leaks also tracked with growth in the spots over time. The results suggest that barrier leaks may mark, or even drive, these common brain changes.
Catalog record
| CREATOR | Richard Leigh, Sarvin Sasannia, Shimeng Wang, Jinwei Zhang, Jerry Prince, Lew Becker, Dhananjay Vaidya, Peter van Zijl, Linda Knutsson, Paul Nyquist |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |