Overcoming disease refractoriness through CD7-targeting CAR T cells in acute myeloid leukemia
Marco Becilli, Franco Locatelli · 2026
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Description
Marco Becilli and Franco Locatelli review work on engineered immune cells for a hard to treat blood cancer. The article from 2026 deals with acute myeloid leukemia that has come back or failed standard care. Cell therapy has changed care for a related blood cancer, but this type has proved harder to target.
The core problem is finding a mark on the cancer cells that is absent on healthy blood stem cells. Hitting the wrong cells could wipe out blood making for good. The authors describe a dual design aimed at a mark called CD7, with a blocker that hides the mark on the therapy cells. A cure now rests on a stem cell transplant after remission.
Catalog record
| CREATOR | Marco Becilli, Franco Locatelli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |