Delineation of the heterogeneity underlying genomic instability in hereditary breast cancers reveals four disease subtypes
Sunmin Kim, Seeyoun Lee, Hyeji Kim, Su Jung Kang, Heejung Chae, Bong-Jo Kim, Jinhwa Kong, Min-Chae Kang, Tae-Min Kim, Sun-Young Kong · 2026
Read Delineation of the heterogeneity underlying genomic instability in hereditary breast cancers reveals four disease subtypes by Sunmin Kim, Seeyoun Lee, Hyeji Kim, Su Jung Kang, Heejung Chae, Bong-Jo Kim, Jinhwa Kong, Min-Chae Kang, Tae-Min Kim, Sun-Young Kong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13144627.txt.
Description
Sunmin Kim and co-authors sort inherited breast cancers by their genome faults in this 2026 study. Such cancers vary widely, yet the faults that drive them were poorly mapped. The team reads the full genomes of tumors from patients whose known risk genes tested clean.
Four subtypes emerge from the fault patterns. One group lacks a key DNA repair path, one piles up small mutations, one stacks copy losses, and one stays fairly stable. Each group shows its own immune and tissue traits. Lab tests hint that the groups answer to unlike drugs, from repair blockers to immune therapy. The authors build a combined score to sort patients for matched care.
Catalog record
| CREATOR | Sunmin Kim, Seeyoun Lee, Hyeji Kim, Su Jung Kang, Heejung Chae, Bong-Jo Kim, Jinhwa Kong, Min-Chae Kang, Tae-Min Kim, Sun-Young Kong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |