FOXO1-mediated cell cycle arrest enhances osteogenic differentiation of spheroid-cultured human periodontal ligament–derived multipotent mesenchymal stromal cells
Sho Hironaka, Satoru Onizuka, Kotaro Sano, Yuichiro Oka, Takenori Suga, Shoichiro Kokabu, Wataru Ariyoshi, Kohji Nakazawa, Shinichi Mochizuki, Michihiko Usui · 2026
Read FOXO1-mediated cell cycle arrest enhances osteogenic differentiation of spheroid-cultured human periodontal ligament–derived multipotent mesenchymal stromal cells by Sho Hironaka, Satoru Onizuka, Kotaro Sano, Yuichiro Oka, Takenori Suga, Shoichiro Kokabu, Wataru Ariyoshi, Kohji Nakazawa, Shinichi Mochizuki, Michihiko Usui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13144600.txt.
Description
Sho Hironaka and nine co-authors study cells taken from the ligament that holds teeth in place, in a research paper from 2026. These cells can help regrow bone lost to gum disease. Growing them as small balls, called spheroids, seems to boost that power, but the reason was not clear.
The team compared genes in ball-grown cells and flat-grown cells. Ball-grown cells slowed their growth cycle and turned on a gene called FOXO1. When FOXO1 was blocked, the cells lost much of their bone-making power. The authors say FOXO1 could be a useful target for new gum and bone treatments.
Catalog record
| CREATOR | Sho Hironaka, Satoru Onizuka, Kotaro Sano, Yuichiro Oka, Takenori Suga, Shoichiro Kokabu, Wataru Ariyoshi, Kohji Nakazawa, Shinichi Mochizuki, Michihiko Usui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |