SOX9 represses the human galectin-3 promoter in SW1353 cells: potential implications for osteoarthritis
Blanca Alba, Shivani Buddiga, Herbert Kaltner, Stefan Toegel, Sebastian Schmidt · 2026
Read SOX9 represses the human galectin-3 promoter in SW1353 cells: potential implications for osteoarthritis by Blanca Alba, Shivani Buddiga, Herbert Kaltner, Stefan Toegel, Sebastian Schmidt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13144414.txt.
Description
Blanca Alba and co-authors published a 2026 study on how a cartilage gene switch controls a protein implicated in osteoarthritis. The protein, galectin-3, helps drive inflammation and the breakdown of cartilage. The team worked in a cartilage-like cell line to find which parts of that region matter, and which control proteins bind there.
Using reporter genes, they trimmed the switch region piece by piece. A short stretch at the gene's start proved essential for activity. Computer scans predicted docking sites for the SOX family of control proteins. A binding test confirmed one of them, SOX9, attaches in that critical stretch. Adding more SOX9 turned the gene down in a dose-dependent way, and slightly lowered its output too. Since SOX proteins go off balance in osteoarthritis, the authors see this link as a clue to the disease.
Catalog record
| CREATOR | Blanca Alba, Shivani Buddiga, Herbert Kaltner, Stefan Toegel, Sebastian Schmidt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |