Novel green synthesis of polyfunctionally substituted phthalazines promoted by visible light, DFT studies and molecular docking with antimicrobial and antibiofilm potency
Ramadan A Mekheimer, Basma A Khalifa, Zeinab Shawky Hashem, Samar M R Allam, Kamal Usef Sadek, Mohamed R Eletmany · 2026
Read Novel green synthesis of polyfunctionally substituted phthalazines promoted by visible light, DFT studies and molecular docking with antimicrobial and antibiofilm potency by Ramadan A Mekheimer, Basma A Khalifa, Zeinab Shawky Hashem, Samar M R Allam, Kamal Usef Sadek, Mohamed R Eletmany (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13144394.txt.
Description
Making useful drug-like molecules with light instead of harsh chemicals is a goal of green chemistry. Ramadan Mekheimer and co-authors report in 2026 a light-driven route to a family of phthalazine compounds, built without metals under a white lamp at room temperature, with open air as the oxidant. Yields were high, and a scavenger test supported a radical pathway.
Two of the new compounds stood out against bacteria. One fought two hard-to-treat species at low doses and blocked biofilm growth by about eighty percent. Computer studies mapped the molecules' shapes, charge patterns, and likely binding to a target enzyme. The authors present the series as a promising start for new antimicrobial leads.
Catalog record
| CREATOR | Ramadan A Mekheimer, Basma A Khalifa, Zeinab Shawky Hashem, Samar M R Allam, Kamal Usef Sadek, Mohamed R Eletmany |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |