Nonionic peptide amphiphiles and their supramolecular co-assemblies tune charge density and bioactivity
Jacob A. Lewis, Ronit Freeman, Tristan D. Clemons, Jacqueline M. Godbe, Nicholas Stephanopoulos, Samuel I. Stupp · 2026
Read Nonionic peptide amphiphiles and their supramolecular co-assemblies tune charge density and bioactivity by Jacob A. Lewis, Ronit Freeman, Tristan D. Clemons, Jacqueline M. Godbe, Nicholas Stephanopoulos, Samuel I. Stupp (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13142779.txt.
Description
Jacob A Lewis is first author on a 2026 chemistry study of peptide amphiphiles, molecules that self-assemble into filaments in water and can act on cells. Such assemblies usually need charged parts to dissolve, but charge can cause cell toxicity and makes structures sensitive to acidity and salt. The team made a nonionic, or uncharged, version.
The uncharged molecules formed long filaments that stayed stable across acidity and salt conditions. Mixing them with charged partners tuned surface charge density, and the mixes were more internally ordered than either kind alone. In a bone-forming cell model, mixes and uncharged assemblies acted more strongly than fully charged ones. Charge tuning may help design safer bioactive nanomaterials.
Catalog record
| CREATOR | Jacob A. Lewis, Ronit Freeman, Tristan D. Clemons, Jacqueline M. Godbe, Nicholas Stephanopoulos, Samuel I. Stupp |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |