VNUT-mediated ATP release suppresses T helper 1 (TH1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade
Bolong Wu, Linlin Sheng, Ziyi Feng, Xiaohu Wang, Ligong Chen · 2025
Read VNUT-mediated ATP release suppresses T helper 1 (TH1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade by Bolong Wu, Linlin Sheng, Ziyi Feng, Xiaohu Wang, Ligong Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13142776.txt.
Description
Bolong Wu and co-authors find a brake on a key immune cell type in this 2025 study. A form of ATP, the cell's energy carrier, acts as a danger signal outside cells and shapes immune responses. T cells store and release this carrier through a transporter, but that side of the process was poorly known.
The transporter is high in one helper T cell type and limits its growth and function. When T cells are triggered, the transporter helps load ATP into storage sacs and release it. The released ATP then sets off a chain of signals that cuts the cells' output of a key defense protein. Blocking the transporter boosted these cells against infection and tumors in tests.
Catalog record
| CREATOR | Bolong Wu, Linlin Sheng, Ziyi Feng, Xiaohu Wang, Ligong Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |