Association between peripheral serotonin levels and postoperative delirium in older adults undergoing gastrointestinal surgery: a single-centre, prospective cohort study protocol
Shujie Wang, Yaqi Han, Kaiqiang Fan, Chuan Guo, Yiwei Lin, Jirun Wang, Yuhang Shi, Shaoqi Tian, Youzhuang Zhu · 2026
Read Association between peripheral serotonin levels and postoperative delirium in older adults undergoing gastrointestinal surgery: a single-centre, prospective cohort study protocol by Shujie Wang, Yaqi Han, Kaiqiang Fan, Chuan Guo, Yiwei Lin, Jirun Wang, Yuhang Shi, Shaoqi Tian, Youzhuang Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13141247.txt.
Description
Shujie Wang and co-authors set out, in a 2026 protocol paper, a study of whether a blood chemical can flag older patients at risk of delirium after gut surgery. Delirium strikes about thirty percent of older adults after such operations, bringing confusion that can last and harm recovery. Gut surgery is known to raise production of serotonin, the chemical in question, but its tie to delirium is unproven.
The single-center study will enroll 314 patients aged sixty and over having planned gut surgery in Qingdao, China. Serotonin will be measured before anesthesia and again after surgery. The main outcome is delirium within three days, scored by trained assessors. Recovery quality, gut function, pain, and complications are also tracked, with a preset causal map guiding the analysis. Consent and ethics approvals are in place.
Catalog record
| CREATOR | Shujie Wang, Yaqi Han, Kaiqiang Fan, Chuan Guo, Yiwei Lin, Jirun Wang, Yuhang Shi, Shaoqi Tian, Youzhuang Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |