Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases
Mario Mandalà, Monica F Chen, Ryan J Sullivan, Maria Chiara Sergi, Michael Postow, Aleigha R Lawless, Derek Effiom, Tobias Peres, Paul C Lorigan, Patricio Serra-Bellver, Reinhard Dummer, Teresa Amaral, Marie-Lena Rasch, Diana Giannarelli, Maria Grazia Vitale, Hildur Helgadottir, Caroline Robert, Mar · 2026
Read Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases by Mario Mandalà, Monica F Chen, Ryan J Sullivan, Maria Chiara Sergi, Michael Postow, Aleigha R Lawless, Derek Effiom, Tobias Peres, Paul C Lorigan, Patricio Serra-Bellver, Reinhard Dummer, Teresa Amaral, Marie-Lena Rasch, Diana Giannarelli, Maria Grazia Vitale, Hildur Helgadottir, Caroline Robert, Mar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13141176.txt.
Description
A large team studies what happens when melanoma patients stop combination immunotherapy in this 2026 paper. The two drug combination is standard care for melanoma that has spread to the brain, but guidelines say little about when responders can safely stop.
The study gathered 465 patients: 392 who stopped within twenty-four months for reasons other than disease growth, and 73 who kept going past that mark. Survival, response, time without growth, and side effects were compared across the groups. Many stops came after complete response. Work like this helps doctors weigh the burden of long treatment against the risk of stopping for patients whose disease has melted away.
Catalog record
| CREATOR | Mario Mandalà, Monica F Chen, Ryan J Sullivan, Maria Chiara Sergi, Michael Postow, Aleigha R Lawless, Derek Effiom, Tobias Peres, Paul C Lorigan, Patricio Serra-Bellver, Reinhard Dummer, Teresa Amaral, Marie-Lena Rasch, Diana Giannarelli, Maria Grazia Vitale, Hildur Helgadottir, Caroline Robert, Mar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |