Fibroblast-mediated KRAS activation in double-negative prostate cancer
Taiki Kamijima, Kouji Izumi, Kaoru Hiratsuka, Takahiro Inaba, Yoshiki Koketsu, Ryunosuke Nakagawa, Ren Toriumi, Shuhei Aoyama, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Hiroki Nakata, Yohei · 2026
Read Fibroblast-mediated KRAS activation in double-negative prostate cancer by Taiki Kamijima, Kouji Izumi, Kaoru Hiratsuka, Takahiro Inaba, Yoshiki Koketsu, Ryunosuke Nakagawa, Ren Toriumi, Shuhei Aoyama, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Hiroki Nakata, Yohei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13139504.txt.
Description
Taiki Kamijima and co-authors uncover a backup engine that drives a stubborn form of prostate cancer. When hormone signaling is blocked, most prostate cancers slow, but many return in a double-negative form that answers neither hormone therapy nor the usual backup plans. The team finds the growth switch KRAS barely matters while hormone signaling runs, then takes over once it is shut off.
The handoff runs through the tumor's neighborhood. Hormone-blocked cancer cells release a signal, CCL2, that makes nearby stromal cells secrete a growth factor, FGF8b. That factor, meeting rewired receptors on the cancer cells, fires KRAS. A pan-KRAS inhibitor shut the cells down and triggered their programmed death, lowering a survival protein and raising a death marker in tumors. The authors name KRAS a target for this treatment-starved cancer type.
Catalog record
| CREATOR | Taiki Kamijima, Kouji Izumi, Kaoru Hiratsuka, Takahiro Inaba, Yoshiki Koketsu, Ryunosuke Nakagawa, Ren Toriumi, Shuhei Aoyama, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Hiroki Nakata, Yohei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |