ENO2 drives tumor cell-induced M2 macrophage polarization to promote colorectal cancer liver metastasis
Junwei Tang, Zhihao Chen, Dongsheng Zhang, Kangpeng Jin, Hengjie Xu, Chuanxin Tian, Jinling Duan, Sheng Yang, Qingyang Sun, Yifei Feng, Xiaowei Wang, Dan Xie, Yueming Sun · 2026
Read ENO2 drives tumor cell-induced M2 macrophage polarization to promote colorectal cancer liver metastasis by Junwei Tang, Zhihao Chen, Dongsheng Zhang, Kangpeng Jin, Hengjie Xu, Chuanxin Tian, Jinling Duan, Sheng Yang, Qingyang Sun, Yifei Feng, Xiaowei Wang, Dan Xie, Yueming Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13139463.txt.
Description
Junwei Tang and twelve co-authors identify a driver of colon cancer spread to the liver, in a study from twenty twenty-six. Liver spread is the main cause of death in this cancer. The team read single-cell gene activity in paired gut tumors, nearby tissue, and liver deposits from patients with and without spread.
Cancer cells rich in an enzyme called ENO2 were far more common in patients with spread. Those cells shifted shape readily and pushed the disease forward in mice. Inside the cells, the enzyme grips a partner protein and shields it from destruction. That signal then recruits immune cells of a type that shelters tumors. Blocking the grip shrank liver spread in mice, and deleting the enzyme did the same. The pair forms a drug target.
Catalog record
| CREATOR | Junwei Tang, Zhihao Chen, Dongsheng Zhang, Kangpeng Jin, Hengjie Xu, Chuanxin Tian, Jinling Duan, Sheng Yang, Qingyang Sun, Yifei Feng, Xiaowei Wang, Dan Xie, Yueming Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |