Genetic Features and Clinical Heterogeneity of Leber Hereditary Optic Neuropathy in Adolescent and Adult Patients: A Case Series on Arab Patients
Esraa Basalem, Nooran Badeeb · 2026
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Description
A rare inherited disease called Leber hereditary optic neuropathy causes painless, fast vision loss, usually in young men. It comes from faults in the DNA of mitochondria, the cell's energy makers. Esraa Basalem and Nooran Badeeb describe a series of patients from Saudi Arabia and Yemen, where reports are scarce.
Most patients carried the same mutation, m.11778G>A, that dominates worldwide. Onset ranged from the teen years into adulthood, and the cases differed in severity and course. Some patients had changeable risk factors that may have helped trigger the disease. Two patients given the drug idebenone improved, and both treated patients did well. Others on a supplement reported better vision that tests could not confirm. The authors urge early genetic testing and treatment, plus lower cost barriers in the region.
Catalog record
| CREATOR | Esraa Basalem, Nooran Badeeb |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |