β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset
Francesca Terrin, Sofia Faggin, Edoardo Bizzotto, Davide Santinello, Silvia Cerantola, Giuseppe Borsato, Fabrizio Fabris, Alessandro Scarso, Rosario Licitra, Graziano Guella, Gabriele Sales, Stefano Cagnin, Laura Treu, Luigi Bubacco, Maria Cecilia Giron, Nicoletta Plotegher, Luisa Dalla Valle · 2026
Read β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset by Francesca Terrin, Sofia Faggin, Edoardo Bizzotto, Davide Santinello, Silvia Cerantola, Giuseppe Borsato, Fabrizio Fabris, Alessandro Scarso, Rosario Licitra, Graziano Guella, Gabriele Sales, Stefano Cagnin, Laura Treu, Luigi Bubacco, Maria Cecilia Giron, Nicoletta Plotegher, Luisa Dalla Valle (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13137512.txt.
Description
Francesca Terrin and co-authors trace a plant compound's harm in a 2026 animal study. The compound, called BSSG, is a sugar-linked plant sterol eaten in some diets, and it has been linked to a disease pairing nerve loss with parkinsonism.
The team fed BSSG to zebrafish and mice and found the gut was the first tissue hit. Intestines swelled with inflammation, changed shape and movement, and shifted their gene activity and gut microbes. These gut changes came before any nerve damage appeared. The order of events suggests the path from this food compound to brain disease may start in the belly, a fresh angle for prevention work.
Catalog record
| CREATOR | Francesca Terrin, Sofia Faggin, Edoardo Bizzotto, Davide Santinello, Silvia Cerantola, Giuseppe Borsato, Fabrizio Fabris, Alessandro Scarso, Rosario Licitra, Graziano Guella, Gabriele Sales, Stefano Cagnin, Laura Treu, Luigi Bubacco, Maria Cecilia Giron, Nicoletta Plotegher, Luisa Dalla Valle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |