Integrating polygenic and transcriptional risk scores for detecting Alzheimer's disease
Jiyun Hwang, Jung‐Min Pyun, Joo‐Yeon Lee, Jeong Su Park, Paula J. Bice, Andrew J. Saykin, Joohon Sung, SangYun Kim, Young Ho Park, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative · 2026
Read Integrating polygenic and transcriptional risk scores for detecting Alzheimer's disease by Jiyun Hwang, Jung‐Min Pyun, Joo‐Yeon Lee, Jeong Su Park, Paula J. Bice, Andrew J. Saykin, Joohon Sung, SangYun Kim, Young Ho Park, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13137284.txt.
Description
Jiyun Hwang and colleagues with the Alzheimer's Disease Neuroimaging Initiative published a risk score study in two thousand twenty-six. Finding Alzheimer's early usually needs costly or invasive tests. Two blood-friendly scores, one from genes and one from gene activity, might flag risk more cheaply.
The team computed both scores in two cohorts, one American and one Korean, totalling under five hundred people. People high on both scores had two and a half to over three times the odds of Alzheimer's compared with low scorers. The combined model sorted patients better than the gene score alone. The authors say pairing fixed genetic risk with live gene activity sharpens early detection across ancestries.
Catalog record
| CREATOR | Jiyun Hwang, Jung‐Min Pyun, Joo‐Yeon Lee, Jeong Su Park, Paula J. Bice, Andrew J. Saykin, Joohon Sung, SangYun Kim, Young Ho Park, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |