BDKRB1 Links Copy Number–Defined Genomic Instability to Inflammatory and Immunosuppressive Tumor Ecosystems in Ovarian Cancer: An Integrative Multiomics Analysis
Dali Pu, Huagui Chen, Xia Wang, Shan He · 2026
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Description
Dali Pu, Huagui Chen, Xia Wang, and Shan He connect a bradykinin receptor gene to the chaotic genomes and hostile immune surroundings of ovarian cancer. This cancer kills at high rates, scrambles its DNA copy numbers widely, and hides from immunity. The receptor, BDKRB1, switches on with inflammation and has been tied to tumor signaling. Their 2026 analysis weaves several omics layers together: gene copies, gene activity, and the immune mix inside tumors. They ask whether tumors with heavy copy changes also raise this receptor and shut out immune attack.
Linking genome instability to an inflamed yet suppressed ecosystem could explain treatment resistance. A single measurable gene at the junction might flag the worst tumors. The authors run an integrative design rather than one data type at a time. Their work is computational, mining existing tumor atlases. It nominates BDKRB1 for lab follow-up.
Catalog record
| CREATOR | Dali Pu, Huagui Chen, Xia Wang, Shan He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |