Prophylactic Left Atrial Appendage Occlusion During Mitral Valve Repair in Patients Without Atral Fibrillation: A Meta‐Analysis of Time to Event Data
Ahmed Emara, Ameer Awashra, Mohamed S Elgendy, Mohamed R Murad, Mohamed Emara, Abubakar Nazir, Abdalhakim Shubietah, Michael Megaly, Vinayak N Bapat · 2026
Read Prophylactic Left Atrial Appendage Occlusion During Mitral Valve Repair in Patients Without Atral Fibrillation: A Meta‐Analysis of Time to Event Data by Ahmed Emara, Ameer Awashra, Mohamed S Elgendy, Mohamed R Murad, Mohamed Emara, Abubakar Nazir, Abdalhakim Shubietah, Michael Megaly, Vinayak N Bapat (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13136685.txt.
Description
Ahmed Emara and co-authors pool trial data on closing the heart's left atrial appendage during valve repair in this 2026 analysis. The small pouch can harbor clots that cause strokes. Patients here had no prior atrial fibrillation, the rhythm fault that usually prompts closure. Whether preventive closure helps them was unclear. The team searched four databases for studies through late 2025. They rebuilt patient timelines from published survival curves.
Rebuilt data allowed a proper time-based pooling across studies. Stroke and other clot events were the main outcomes weighed. Safety over the long term was the other half of the question. Adding a step to surgery needs proven benefit to justify it. The analysis is a meta-study of earlier trials. It speaks to surgeons planning mitral repair.
Catalog record
| CREATOR | Ahmed Emara, Ameer Awashra, Mohamed S Elgendy, Mohamed R Murad, Mohamed Emara, Abubakar Nazir, Abdalhakim Shubietah, Michael Megaly, Vinayak N Bapat |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |